Brand name: Mavenclad.
Generic name: Cladribine.
Who takes it?:
Adults with Very Active Relapsing Remitting MS (2 relapses in 1 year and MRI changes) or relapsing on another DMT.
Mavenclad reduces relapses up to 58%. Studies also showed that MRI scans show smaller or no new lesions and may also slow down disability.
Mavenclad should not be taken in pregnancy, women who are of child bearing age should be using an effective contraception whilst taking Mavenclad and also for 6 months after stopping. Men should also be using barrier contraception whilst on treatment and after for 6 months.
Mavenclad may not be used if you have liver or kidney problems, cancer, HIV, hepatitis or TB.
How is it given?:
Mavenclad is an oral tablet that is taken in 2 treatment courses. The first course is for 5 days in a row in the first month, and again for 5 days in the second month. The second course is just like the first one and is repeated after 12 months.
The dose of Mavenclad is based on your weight.
Who Monitors it?:
Bloods are obtained prior to treatment, after month 3 and 7 and then pre next dose. You will be informed when they are due, we will ask you either to attend your Gp practice or the MS Nurse home phlebotomy service will collect them. The MS Nurse phlebotomy service, can come to your home environment or after negotiation with your employer, at your work place.
At each MS Nurse appointment you will be asked about your Mavenclad:
- Have any side effects.
- Had any infections.
- Discuss blood results.
Side effects:
- Reduced white cell count.
- Cold sores.
- Rash.
- Hair loss.
- TB
Travel:
This medication does not need to be kept in your hand luggage when travelling abroad, however we suggest you do, due to main luggage occasionally being lost or delayed.
Vaccine:
Whilst on Mavenclad we advice that you do not have Live or Live-attenuated vaccines, please call us for further advice.
https://www.mssociety.org.uk/care-and-support/health-and-social-care/health-care/flu-jabs
Support:
https://mstrust.org.uk/a-z/mavenclad-cladribine